Ullrich A, Bell J R, Chen E Y, Herrera R, Petruzzelli L M, Dull T J, Gray A, Coussens L, Liao Y C, Tsubokawa M
Nature. 1985;313(6005):756-61. doi: 10.1038/313756a0.
We have deduced the entire 1,370-amino-acid sequence of the human insulin receptor precursor from a single complementary DNA clone. The precursor starts with a 27-amino-acid signal sequence, followed by the receptor alpha-subunit, a precursor processing enzyme cleavage site, then the beta-subunit containing a single 23-amino-acid transmembrane sequence. There are sequence homologies to human epidermal growth factor receptor and the members of the src family of oncogene products.
我们从一个单一的互补DNA克隆中推导得到了人胰岛素受体前体完整的1370个氨基酸的序列。该前体起始于一个27个氨基酸的信号序列，接着是受体α亚基、一个前体加工酶切割位点，然后是包含一个23个氨基酸单一跨膜序列的β亚基。其序列与人表皮生长因子受体以及癌基因产物src家族成员存在同源性。
