Huang Qingchun, Qian Xuhong, Song Gonghua, Cao Song
Institute of Pesticides and Pharmaceuticals, East China University of Science and Technology, Shanghai, 200237, China.
Pest Manag Sci. 2003 Aug;59(8):933-9. doi: 10.1002/ps.704.
The toxicities and anti-feedant activities of thirteen asymmetrical 1,3,4-oxadiazoles containing a 2H-pyridazin-3-one group were investigated. The compounds were shown to possess considerable activity in retarding the development of larvae of a number of Lepidoptera, but they were all inactive against Homoptera, Diptera and Acarina. The compounds had powerful anti-feedant activity comparable with that of azadirachtin. The toxic symptoms of the poisoned larvae indicated that the compounds were novel insect growth regulators with a mode of action that might be similar to the chitin-synthesis inhibition of oxadiazole compounds and/or the juvenile hormone effect of pyridazinone compounds.
研究了13种含2H-哒嗪-3-酮基团的不对称1,3,4-恶二唑的毒性和拒食活性。结果表明，这些化合物在抑制多种鳞翅目幼虫发育方面具有相当的活性，但对同翅目、双翅目和蜱螨目均无活性。这些化合物具有与印楝素相当的强大拒食活性。中毒幼虫的毒性症状表明，这些化合物是新型昆虫生长调节剂，其作用方式可能类似于恶二唑化合物对几丁质合成的抑制作用和/或哒嗪酮化合物的保幼激素效应。
