新型恶二唑基3（2H）哒嗪酮的合成及其拒食活性

Synthesis and antifeedant activity of new oxadiazolyl 3(2H)-pyridazinones.

作者信息

Cao Song, Qian Xuhong, Song Gonghua, Chai Bing, Jiang Zhisheng

机构信息

Institute of Pesticides and Pharmaceuticals, East China University of Science and Technology, P.O. Box 544, 130 Meilong Road, Shanghai 200237, P. R. China.

出版信息

J Agric Food Chem. 2003 Jan 1;51(1):152-5. doi: 10.1021/jf0208029.

DOI:10.1021/jf0208029

PMID:12502400

Abstract

A total of 20 new compounds containing the oxadiazolyl 3(2H)-pyridazinone moiety were synthesized. The structures of all the compounds were confirmed by (1)H NMR, IR, MS, and elemental analysis. Their insect antifeedant activities against Asiatic corn borer Ostrinia furnacalis (Guenee) were examined and compared with commercial azadirachtin. The compounds exhibited significant levels of activity. The feeding deterrency values of IIIa,j were 57% and 51% at 500 mg/kg concentration, respectively.

摘要

总共合成了20种含有恶二唑基-3(2H)-哒嗪酮部分的新化合物。所有化合物的结构均通过¹H NMR、IR、MS和元素分析得以确证。检测了它们对亚洲玉米螟Ostrinia furnacalis (Guenee)的拒食活性，并与市售印楝素进行了比较。这些化合物表现出显著的活性水平。化合物IIIa、j在500 mg/kg浓度下的拒食率分别为57%和51%。