Briganti Alberto, Salonia Andrea, Deho Federico, Zanni Giuseppe, Rokkas Konstantinos, Rigatti Patrizio, Montorsi Francesco
Department of Urology, Universita Vita Salute Raffaele, Milan, Italy.
Curr Opin Urol. 2003 Sep;13(5):417-22. doi: 10.1097/00042307-200309000-00010.
This review is aimed to summarize the most recent findings about this topic, by reviewing the literature published in 2002 and 2003 regarding the epidemiology, pathophysiology, diagnosis and treatment of Peyronie's disease.
Although many aspects in pathophysiology, diagnosis, medical and surgical treatment of Peyronie's disease still remain under debate, recent interesting advances have been made regarding the different aspects of this condition. Topical and systemic medical therapies have been associated with varying degrees of results, depending on modalities and timing of the treatment itself. A wide range of surgical modalities have been recently developed, although the ideal surgical procedure especially in case of severe and complex curvature does not seem to be reached yet. Furthermore this condition is often associated with psychological distress that could be responsible for performance anxiety, leading to improvement of abnormalities in erectile functioning eventually associated with Peyronie's disease.
Peyronie's disease consists of an acquired penile deformity caused by the formation of fibrous plaques within the tunica albuginea, leading to bio-mechanical and vascular abnormalities. In the last decade numerous advances have been made regarding pathophysiology, diagnosis and treatment of this condition, allowing for improved patient clinical prognosis. Nevertheless, although improvements in medical and surgical therapies have substantially increased the successful patients' outcome rate, Peyronie's disease is still not completely understood and its treatment remains often frustrating for the practicing urologist. Clinical presentations of this disease include penile deformities or shortening during erection, painful erection, palpable plaque or induration throughout the length of the penile shaft and erectile dysfunction.
本综述旨在通过回顾2002年和2003年发表的有关佩罗尼氏病的流行病学、病理生理学、诊断和治疗的文献，总结该主题的最新研究结果。
尽管佩罗尼氏病的病理生理学、诊断、药物和手术治疗的许多方面仍存在争议，但在这种疾病的不同方面已取得了一些有趣的新进展。局部和全身药物治疗根据治疗方式和时机的不同，取得了不同程度的效果。最近已开发出多种手术方式，不过对于严重和复杂弯曲的情况，似乎尚未找到理想的手术方法。此外，这种疾病常伴有心理困扰，可能导致性交焦虑，最终导致与佩罗尼氏病相关的勃起功能异常得到改善。
佩罗尼氏病是一种后天性阴茎畸形，由白膜内纤维斑块的形成引起，导致生物力学和血管异常。在过去十年中，关于这种疾病的病理生理学、诊断和治疗取得了许多进展，改善了患者的临床预后。然而，尽管药物和手术治疗的改进显著提高了成功患者的治愈率，但佩罗尼氏病仍未被完全理解，其治疗对泌尿外科医生来说常常令人沮丧。这种疾病的临床表现包括勃起时阴茎畸形或缩短、勃起疼痛、阴茎轴全长可触及斑块或硬结以及勃起功能障碍。
