Department of Urology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Department of Urology, University of Miami, Miami, FL, USA.
Sex Med Rev. 2019 Jul;7(3):499-507. doi: 10.1016/j.sxmr.2019.02.001. Epub 2019 Mar 26.
Peyronie's disease is an acquired condition of the connective tissue of the penis that affects 0.5-20.3% of the male population and is marked by fibrotic plaques in the tunica albuginea. It can result in penile curvature/deviation, painful erections, and sexual dysfunction. Several treatment modalities have been proposed, with studies from the past decade investigating extracorporeal shockwave therapy's (ESWT) potential efficacy in Peyronie's management.
To investigate the effects of ESWT on Peyronie's disease parameters such as penile curvature, plaque size, erectile function, and penile pain.
We reviewed the literature examining the effects of ESWT on Peyronie's disease.
The main outcome measures after receiving extracoporeal shockwave therapy included changes in degree of penile curvature, penile plaque size, International Index of Erectile Function-5 questionnaire score, and visual analogue scale score.
Randomized controlled trials examining the efficacy of ESWT in Peyronie's disease do not show a statistically significant benefit in curvature reduction, plaque size, or erectile function, although a recent meta-analysis demonstrates a benefit in plaque size reduction. A statistically significant reduction in penile pain has been observed across multiple studies.
Extracorporeal shockwave therapy may be beneficial in the management of Peyronie's disease for refractory penile pain and plaque size reduction. However, penile pain typically resolves spontaneously over time, and shockwave therapy can pose a substantial financial burden to patients. A multi-institutional randomized controlled trial with standardization of methods and strict inclusion criteria regarding disease duration would prove beneficial in determining the true efficacy of shockwave therapy in Peyronie's disease. Krieger JR, Rizk PJ, Kohn TP, et al. Shockwave Therapy in the Treatment of Peyronie's Disease. Sex Med Rev 2019;7:499-507.
佩罗尼氏病是一种男性生殖器结缔组织的后天性疾病，影响 0.5-20.3%的男性人群，其特征是白膜中有纤维斑块。它可导致阴茎弯曲/偏斜、勃起疼痛和性功能障碍。已经提出了几种治疗方法，过去十年的研究调查了体外冲击波治疗（ESWT）在佩罗尼氏病管理中的潜在疗效。
研究 ESWT 对佩罗尼氏病参数的影响，如阴茎弯曲度、斑块大小、勃起功能和阴茎疼痛。
我们回顾了研究 ESWT 对佩罗尼氏病影响的文献。
接受体外冲击波治疗后的主要观察指标包括阴茎弯曲度、阴茎斑块大小、国际勃起功能指数-5 问卷评分和视觉模拟评分的变化。
检查 ESWT 在佩罗尼氏病中的疗效的随机对照试验并没有显示在曲率减小、斑块大小或勃起功能方面有统计学上的显著益处，尽管最近的一项荟萃分析显示在斑块大小减小方面有好处。多项研究观察到阴茎疼痛有统计学意义的减少。
体外冲击波治疗可能有助于治疗佩罗尼氏病的难治性阴茎疼痛和斑块大小减小。然而，阴茎疼痛通常会随着时间的推移而自发缓解，并且冲击波治疗可能会给患者带来巨大的经济负担。进行一项多机构、随机对照试验，方法标准化，并严格规定疾病持续时间的纳入标准，将有助于确定冲击波治疗在佩罗尼氏病中的真正疗效。克里格 JR，里兹克 PJ，科恩 TP 等人。冲击波治疗佩罗尼氏病。性医学评论 2019;7:499-507.
