Newcomer Laura M, Newcomb Polly A, Trentham-Dietz Amy, Longnecker Matthew P, Greenberg E Robert
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Int J Cancer. 2003 Oct 10;106(6):961-4. doi: 10.1002/ijc.11307.
We examined the association between oral contraceptive use and risk of specific breast cancer histopathologies in a large, multi-center, population-based, case-control study. Women younger than age 75 with a new diagnosis of invasive breast cancer were identified from 4 statewide tumor registries. We compared women with lobular (n = 493) and ductal carcinoma (n = 5,510) to randomly selected controls (n = 9,311). Odds ratios (OR) and 95% confidence intervals (CI) for each histologic type were estimated using polytomous logistic regression, adjusted for other breast cancer risk factors. Current oral contraceptive use was associated with increased risk of lobular carcinoma (OR = 2.6, 95%CI = 1.0-7.1) and there was a significant trend (p = 0.017) of increased risk with more recent use. Oral contraceptive use was not clearly associated with ductal carcinoma (OR = 1.2, 95%CI = 0.8-1.9). These results suggest that the association between oral contraceptive use and risk of breast cancer may vary by histologic type.
在一项大型、多中心、基于人群的病例对照研究中，我们研究了口服避孕药的使用与特定乳腺癌组织病理学风险之间的关联。从4个全州范围的肿瘤登记处识别出年龄小于75岁且新诊断为浸润性乳腺癌的女性。我们将小叶癌患者（n = 493）和导管癌患者（n = 5510）与随机选择的对照组（n = 9311）进行比较。使用多分类逻辑回归估计每种组织学类型的优势比（OR）和95%置信区间（CI），并对其他乳腺癌风险因素进行调整。当前使用口服避孕药与小叶癌风险增加相关（OR = 2.6，95%CI = 1.0 - 7.1），并且随着近期使用，风险有显著增加趋势（p = 0.017）。口服避孕药的使用与导管癌没有明显关联（OR = 1.2，95%CI = 0.8 - 1.9）。这些结果表明，口服避孕药的使用与乳腺癌风险之间的关联可能因组织学类型而异。
