丙型肝炎病毒对病毒性肝炎及血液透析患者的致病性
Pathogenicity of GB virus C on virus hepatitis and hemodialysis patients.
作者信息
Zhu Wan-Fu, Yin Li-Min, Li Peng, Huang Jian, Zhuang Hui
机构信息
Department of Microbiology, School of Basic Medical Sciences, Peking University, Beijing 100083, China.
出版信息
World J Gastroenterol. 2003 Aug;9(8):1739-42. doi: 10.3748/wjg.v9.i8.1739.
AIM
To determine the pathogenicity of GB virus C (GBV-C) on liver and the effects of its co-infection on the clinical features and prognosis of patients with hepatitis B and C.
METHODS
Cross-sectional study was carried out in 413 patients with acute, chronic hepatitis B or liver cirrhosis, and in 67 hemodialysis patients. A 20-month prospective cohort study was carried out in 95 hepatitis B and 80 hepatitis C patients. A reverse transcriptase nested polymerase chain reaction (RT-nPCR) of the 5'-noncoding region was used to detect circulating GBV-C RNA. Liver function was determined by an automated analyzer for all patients.
RESULTS
The prevalence of GBV-C in the high-risk populations with the virus transmitted via blood was high, ranging from 16.2 to 28.8 %. Co-infection with GBV-C in hepatitis B patients did not affect the clinical features of the disease or liver function. The dialysis patients infected with GBV-C alone did not develop functional changes to the liver. Prospective cohort study showed that GBV-C co-infection did not affect the clinical features, prognosis or negative serum conversion rate of chronic hepatitis B and C.
CONCLUSION
The results suggest that GBV-C has no marked pathogenicity on liver, so it may not be a hepatitis virus.
目的
确定GB病毒C型（GBV-C）对肝脏的致病性及其合并感染对乙型和丙型肝炎患者临床特征及预后的影响。
方法
对413例急性、慢性乙型肝炎或肝硬化患者以及67例血液透析患者进行横断面研究。对95例乙型肝炎患者和80例丙型肝炎患者进行了为期20个月的前瞻性队列研究。采用5'-非编码区逆转录巢式聚合酶链反应（RT-nPCR）检测循环GBV-C RNA。所有患者均用自动分析仪测定肝功能。
结果
经血液传播病毒的高危人群中GBV-C感染率较高，为16.2%至28.8%。乙型肝炎患者合并感染GBV-C不影响疾病的临床特征或肝功能。单独感染GBV-C的透析患者肝脏未出现功能改变。前瞻性队列研究表明，GBV-C合并感染不影响慢性乙型和丙型肝炎的临床特征、预后或血清阴转率。
结论
结果提示GBV-C对肝脏无明显致病性，因此它可能不是一种肝炎病毒。
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