呋喃唑酮与哌替啶在兔体内的相互作用。
Furazolidone-pethidine interaction in rabbits.
作者信息
Eltayeb I B, Osman O H
出版信息
Br J Pharmacol. 1975 Dec;55(4):497-501. doi: 10.1111/j.1476-5381.1975.tb07424.x.
1 The intravenous injection of pethidine in rabbits pretreated with furazolidone administered orally but not systemically resulted in severe interaction and fatal hyperpyrexia. 2 Treatment with rho-chlorophenylalanine, chloropromazine of cyproheptadine protected the rabbits against the furazolidone-pethidine interaction, while alpha-methyl-rho-tyrosine was ineffective. 3 5-Hydroxytryptophan produced a fatal hyperpyrexia in furazolidone pretreated rabbits. 4 Pretreatment of rabbits with 1,1,1-trichloro-2, 2-bis(rho-chlorophenyl)ethane (DDT) accelerated and enhanced the furazolidone-pethidine interaction, while oxytetracycline pretreatment completely prevented the interaction. 5 It is concluded that furazolidone-pethidine interaction might depend mainly on potentiation of the effects of 5-hydroxytryptamine in the CNS and that the transformation of furazolidone into an active monoamine oxidase inhibitor metabolite might occur mainly in the gut microflora in the gut lumen.
- 对口服但非全身给药的呋喃唑酮预处理的家兔静脉注射哌替啶，会导致严重的相互作用和致命的高热。2. 用对氯苯丙氨酸、氯丙嗪或赛庚啶治疗可保护家兔免受呋喃唑酮 - 哌替啶相互作用的影响，而α - 甲基对酪氨酸则无效。3. 5 - 羟色氨酸在呋喃唑酮预处理的家兔中产生致命的高热。4. 用1,1,1 - 三氯 - 2,2 - 双（对氯苯基）乙烷（滴滴涕）预处理家兔会加速并增强呋喃唑酮 - 哌替啶相互作用，而土霉素预处理可完全防止这种相互作用。5. 得出的结论是，呋喃唑酮 - 哌替啶相互作用可能主要取决于中枢神经系统中5 - 羟色胺作用的增强，并且呋喃唑酮向活性单胺氧化酶抑制剂代谢物的转化可能主要发生在肠腔中的肠道微生物群中。
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