Galus K, Talalaj M, Madej K, Wall W, Orlowski T
Transplantation Institute, Warsaw Medical School, Poland.
Miner Electrolyte Metab. 1992;18(6):337-42.
The effects of sodium fluoride and calcidiol on the remodeling of the rib cortical-endosteal surface were compared in dogs treated with prednisone over long-term periods. In the study histomorphometric and tetracycline-labeling methods were used. It was found that administration of sodium fluoride in combination with calcidiol and calcium carbonate limited the development of prednisone-induced osteoporosis to a higher degree than treatment with calcidiol and calcium. This included less enhancement of the bone resorption surface, an increase in both the bone formation surface and osteoid seam thickness in conjunction with a lower reduction in the mineralization rate. The changes induced by sodium fluoride had a favorable effect on the ratio of the resorption to the formation processes at the basal multicellular units of bone turnover.
在长期接受泼尼松治疗的犬中，比较了氟化钠和骨化二醇对肋骨皮质 - 骨内膜表面重塑的影响。在该研究中使用了组织形态计量学和四环素标记方法。结果发现，与骨化二醇和钙剂治疗相比，氟化钠联合骨化二醇和碳酸钙给药能更大程度地限制泼尼松诱导的骨质疏松症的发展。这包括骨吸收表面的增强较少，骨形成表面和类骨质缝厚度增加，同时矿化率降低较少。氟化钠引起的变化对骨转换基础多细胞单位处吸收与形成过程的比例产生了有利影响。
