Galus K, Tałałaj M
Instytutu Transplantologii Akademii Medycznej w Warszawie.
Pol Arch Med Wewn. 1993 Apr;89(4):286-92.
The effect of 7 month prednisone administration on cancellous and compact bone remodeling in dogs was evaluated by means of histomorphometric and tetracycline labeling methods. It was found that treatment with prednisone resulted in decrease of bone mass which was caused by increased bone resorption as well as considerable diminution of bone formation. In the iliac bone those were manifested by increase in resorption of trabecular surface, decrease in osteoid surface, and reduction in the osteoid thickness, indicating, with a simultaneous decrease in mineralization rate, slowing down of the appositional rate of newly formed bone tissue. In the rib cortical bone treatment with prednisone resulted in increase of the resorption sites together with decrease of the formation sites and tetracycline-labeled osteons. Reduction in the osteoid thickness as well as in the mineralization rate was also observed. The changes of bone remodeling parameters due to prednisone, although proceeding in the same direction in both types of bone tissue, were more marked in the spongy bone than in the compact bone.
通过组织形态计量学和四环素标记法评估了泼尼松给药7个月对犬松质骨和密质骨重塑的影响。发现泼尼松治疗导致骨量减少，这是由骨吸收增加以及骨形成显著减少引起的。在髂骨中，这些表现为小梁表面吸收增加、类骨质表面减少和类骨质厚度降低，同时矿化率降低，表明新形成的骨组织沉积速率减慢。在肋骨皮质骨中，泼尼松治疗导致吸收部位增加，同时形成部位和四环素标记骨单位减少。还观察到类骨质厚度和矿化率降低。泼尼松引起的骨重塑参数变化，虽然在两种骨组织中都朝着相同方向进行，但在松质骨中比在密质骨中更明显。
