Chen S M, Young T K
Department of Medical Research, Veterans General Hospital-Taipei, Taiwan.
Miner Electrolyte Metab. 1992;18(6):349-53.
Platelet-reduced glutathione (GSH), superoxide dismutase (SOD) and zinc content as well as malondialdehyde (MDA) formation were studied in 24 healthy volunteers as controls and 25 patients with chronic renal failure. Uremic patients had a significantly lower GSH and SOD content as well as an abnormal MDA formation in platelets. Their plasma zinc levels were sharply below the normal value, but the platelet zinc content was similar to normal controls. The decrease in the platelet GSH level was closely related to plasma zinc in uremic patients. We also found that the platelet zinc levels were positively correlated to the platelet GSH content in normal controls and uremic patients, but not to the platelet SOD level. The results suggest that uremic toxins may influence the content of platelet GSH and SOD, as well as inhibit prostaglandin synthesis. The decreases in platelet GSH may partially be related to the low plasma zinc level.
对24名健康志愿者作为对照组以及25名慢性肾衰竭患者，研究了血小板中还原型谷胱甘肽（GSH）、超氧化物歧化酶（SOD）和锌含量以及丙二醛（MDA）的形成情况。尿毒症患者血小板中的GSH和SOD含量显著降低，MDA形成异常。他们的血浆锌水平明显低于正常值，但血小板锌含量与正常对照组相似。尿毒症患者血小板GSH水平的降低与血浆锌密切相关。我们还发现，正常对照组和尿毒症患者的血小板锌水平与血小板GSH含量呈正相关，但与血小板SOD水平无关。结果表明，尿毒症毒素可能影响血小板GSH和SOD的含量，并抑制前列腺素合成。血小板GSH的降低可能部分与血浆锌水平低有关。
