Delaney Sarah, Barton Jacqueline K
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.
J Org Chem. 2003 Aug 22;68(17):6475-83. doi: 10.1021/jo030095y.
The stack of base pairs within double helical DNA has been shown to mediate charge transport reactions. Charge transport through DNA can result in chemistry at a distance, yielding oxidative DNA damage at a site remote from the bound oxidant. Since DNA charge transport chemistry depends on coupling within the stacked base pair array, this chemistry is remarkably sensitive to sequence-dependent DNA structure and dynamics. Here, we discuss different features of DNA charge transport chemistry, including applications as well as possible biological consequences and opportunities.
双螺旋DNA内的碱基对堆叠已被证明可介导电荷转移反应。通过DNA的电荷转移可导致远距离化学反应，在远离结合氧化剂的位点产生氧化性DNA损伤。由于DNA电荷转移化学依赖于堆叠碱基对阵列内的耦合，这种化学对序列依赖性DNA结构和动力学非常敏感。在这里，我们讨论DNA电荷转移化学的不同特征，包括其应用以及可能的生物学后果和机遇。
