心血管系统。
The cardiovascular system.
作者信息
Moore A, Mangoni A A, Lyons D, Jackson S H D
机构信息
Department of Health Care of the Elderly, Guy's, King's, and St Thomas' School of Medicine, King's College Hospital (Dulwich), East Dulwich Grove, London SE22 8PT, UK.
出版信息
Br J Clin Pharmacol. 2003 Sep;56(3):254-60. doi: 10.1046/j.0306-5251.2003.01876.x.
Abstract
The ageing process is associated with important changes in the responses of the cardiovascular system to pharmacological stimuli. They are not limited to the arterial system, involved in the modulation of cardiac afterload and vascular resistance, but they also involve the low-resistance capacitance venous system and the heart. The main changes include loss of large artery compliance, dysfunction of some of the systems modulating resistance vessel tone, increased activity of the sympathetic nervous system, and reduced haemodynamic responses to inotropic agents. This review focuses on the effects of ageing on arterial and venous reactivity to drugs and hormones, the autonomic nervous system, and the cardiovascular responses to inotropic agents. Some of the age-related changes might be at least partially reversible. This may have important therapeutic implications.
摘要
衰老过程与心血管系统对药物刺激的反应发生重要变化有关。这些变化不仅限于参与调节心脏后负荷和血管阻力的动脉系统，还涉及低阻力容量静脉系统和心脏。主要变化包括大动脉弹性丧失、一些调节阻力血管张力的系统功能障碍、交感神经系统活性增加以及对正性肌力药物的血流动力学反应降低。本综述重点关注衰老对动脉和静脉对药物和激素的反应性、自主神经系统以及对正性肌力药物的心血管反应的影响。一些与年龄相关的变化可能至少部分是可逆的。这可能具有重要的治疗意义。
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