Niizeki H, Yokoyama M, Inamoto N, Nishikawa T, Naruse T, Inoko H, Hashigucci K
Department of Dermantolgy and Clinical Research Institute, National Tokyo Medical Center, Japan.
Eur J Immunogenet. 2003 Aug;30(4):249-52. doi: 10.1046/j.1365-2370.2003.00403.x.
We analysed a polymorphism of the interleukin (IL)-1 receptor antagonist (IL1RN) gene in 93 Japanese patients with palmoplantar pustulosis (PPP). None of the IL1RN alleles was significantly increased in the patients compared with controls. Because PPP has been reported to be associated with the tumour necrosis factor (TNF) region, we examined the association between the TNF and IL1RN genes. There was a difference in IL1RN*2 positivity between patients with and without the AA genotype of the TNF gene. In contrast, such a difference was not found in controls. These data indicate a possible epistatic effect between TNF and IL1RN linked genes for susceptibility to the pathogenesis of PPP.
我们分析了93例日本掌跖脓疱病（PPP）患者白细胞介素（IL）-1受体拮抗剂（IL1RN）基因的多态性。与对照组相比，患者中IL1RN等位基因均无显著增加。由于据报道PPP与肿瘤坏死因子（TNF）区域相关，我们检测了TNF和IL1RN基因之间的关联。TNF基因AA基因型患者与非AA基因型患者之间在IL1RN*2阳性方面存在差异。相比之下，在对照组中未发现此类差异。这些数据表明，TNF和IL1RN连锁基因之间可能存在上位效应，影响PPP发病机制的易感性。
