Hurme M, Helminen M
Department of Microbiology and Immunology, University of Tampere Medical School, Finland.
Scand J Infect Dis. 1998;30(5):447-9. doi: 10.1080/00365549850161403.
To examine whether there are genetic differences between cytomegalovirus (CMV)-seronegative and CMV-seropositive adults, the polymorphisms of cytokine genes were analysed in a cohort of 400 adult blood donors. The genes and polymorphic sites studied were the tumour necrosis factor-alpha (TNF-alpha) gene (base exchange polymorphism at position -308; alleles TNF1 and TNF2) and the interleukin-1 receptor antagonist (IL-1RA) gene (variable numbers of 86-bp repeats in intron 2). In this material there were 85 (21%) seronegative persons. The frequencies of the TNF2 and the IL-IRA allele 2 (IL1RN*2) carriers were slightly increased in the seronegative compared with the seropositive samples (39% vs. 29%, and 55% vs. 47%, respectively). The presence of both of these alleles together was significantly (p < 0.05, chi2-test) more frequent in the seronegative population. These data suggest that the alleles of these cytokines, which are known to be associated with a strong inflammatory reaction, may have a protective role against CMV infection.
为了研究巨细胞病毒（CMV）血清阴性和血清阳性成年人之间是否存在基因差异，对400名成年献血者队列中的细胞因子基因多态性进行了分析。所研究的基因和多态性位点包括肿瘤坏死因子-α（TNF-α）基因（-308位碱基交换多态性；等位基因TNF1和TNF2）和白细胞介素-1受体拮抗剂（IL-1RA）基因（内含子2中86 bp重复序列的可变数目）。在该样本中，有85名（21%）血清阴性者。与血清阳性样本相比，血清阴性样本中TNF2和IL-1RA等位基因2（IL1RN*2）携带者的频率略有增加（分别为39%对29%，55%对47%）。在血清阴性人群中，这两种等位基因同时存在的情况显著更常见（p<0.05，卡方检验）。这些数据表明，已知与强烈炎症反应相关的这些细胞因子的等位基因可能对CMV感染具有保护作用。
