Luo Xian-rong, Li Zhuo-liang, Cheng Tao, Wu Wei-ling, Liu Shu-ren, Xie Qing
Department of Infectious Disease, The 458 th Hospital of People's Liberation Army, Guangzhou 510602, Guangdong, China.
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2003 Aug;15(8):499-501.
To analyze the clinical features of severe acute respiratory syndrome (SARS).
The clinical features of 35 patients with SARS in the past five months were retrospectively studied, and compared with 35 patients with community-acquired pneumonia. Consecutive blood samples from 13 patients with SARS and 10 healthy volunteers were collected. The CD+4 and CD+8 in T cell in peripheral blood were detected by flow cytometry.
The most common symptoms included fever (in 100.0 percent of the patients), cough (74.3 percent), headache (45.7 percent), myalgia (45.7 percent) and lymphopenia (20/33). Serial chest radiographs showed progressive multi-infiltration in the lung fields. The CD+4 and CD+8 in T cell in 13 patients with SARS significantly decreased [CD+4: (16.10+/-4.31) percent vs. (38.30+/-8.52) percent, t=8.174,P<0.01; CD+8: (19.90+/-5.40) percent vs. (28.38+/-4.33) percent, t=4.055, P<0.01]. The time of bringing down the fever and the time of absorption of pathological changes in SARS patients were prolonged than those of the pneumonia patients [the time of bringing down the fever (13.92+/-8.35) days vs. (3.86+/-1.42)days, t=16.490,P=0.000;the time of absorption of pathological changes: (11.97+/-4.41) days vs. (9.21+/-4.42) days, t=3.082,P=0.003].
SARS is a serious respiratory illness, the most common symptoms are fever, cough, headache and myalgia, other common findings are lymphopenia, the CD+4 and CD+8 in T cell in peripheral blood decrease and multi-infiltrate through out the lung fields.
分析重症急性呼吸综合征（SARS）的临床特征。
回顾性研究过去五个月内35例SARS患者的临床特征，并与35例社区获得性肺炎患者进行比较。收集13例SARS患者和10名健康志愿者的连续血样。采用流式细胞术检测外周血T细胞中的CD4+和CD8+。
最常见的症状包括发热（100.0%的患者）、咳嗽（74.3%）、头痛（45.7%）、肌痛（45.7%）和淋巴细胞减少（20/33）。系列胸部X线片显示肺部进行性多灶浸润。13例SARS患者外周血T细胞中的CD4+和CD8+显著降低[CD4+：（16.10±4.31）%对（38.30±8.52）%，t = 8.174，P < 0.01；CD8+：（19.90±5.40）%对（28.38±4.33）%，t = 4.055，P < 0.01]。SARS患者退热时间和病变吸收时间比肺炎患者延长[退热时间（13.92±8.35）天对（3.86±1.42）天，t = 16.490，P = 0.000；病变吸收时间：（11.97±4.41）天对（9.21±4.42）天，t = 3.082，P = 0.003]。
SARS是一种严重的呼吸系统疾病，最常见症状为发热、咳嗽、头痛和肌痛，其他常见表现为淋巴细胞减少、外周血T细胞中的CD4+和CD8+降低以及肺部多灶浸润。
