Sobel Burton E, Taatjes Douglas J, Schneider David J
Department of Medicine, University of Vermont, Burlington, USA.
Arterioscler Thromb Vasc Biol. 2003 Nov 1;23(11):1979-89. doi: 10.1161/01.ATV.0000091250.53231.4D. Epub 2003 Aug 14.
Altered expression of plasminogen activator inhibitor type-1 in vessel walls, reviewed here, might affect coronary atherogenesis. Upregulation might exacerbate vasculopathy by potentiating thrombosis and by inhibiting vascular smooth muscle cell migration, resulting in attenuation of thickness of elaborated fibrous caps implicated in the vulnerability of atheroma to rupture.
本文综述的血管壁中1型纤溶酶原激活物抑制剂表达的改变可能会影响冠状动脉粥样硬化的发生。上调可能通过增强血栓形成和抑制血管平滑肌细胞迁移而加剧血管病变，导致参与动脉粥样硬化斑块破裂易损性的精细纤维帽厚度变薄。
