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1
BRCA1 and BRCA2 mutations have no major role in predisposition to prostate cancer in Finland.在芬兰，BRCA1和BRCA2基因突变在前列腺癌易感性方面没有主要作用。
J Med Genet. 2003 Aug;40(8):e98. doi: 10.1136/jmg.40.8.e98.
2
Founder mutations in BRCA1/2 are not frequent in Canadian Ashkenazi Jewish men with prostate cancer.在患有前列腺癌的加拿大德系犹太人男性中，BRCA1/2基因的始祖突变并不常见。
BMC Med Genet. 2003 Aug 11;4:7. doi: 10.1186/1471-2350-4-7.
3
Clinical management of BRCA1 and BRCA2 mutation carriers.BRCA1和BRCA2基因突变携带者的临床管理。
Nat Clin Pract Oncol. 2006 Jan;3(1):2-3. doi: 10.1038/ncponc0384.
4
Male BRCA mutation carriers: clinical characteristics and cancer spectrum.男性 BRCA 基因突变携带者：临床特征和癌症谱。
BMC Cancer. 2018 Feb 13;18(1):179. doi: 10.1186/s12885-018-4098-y.
5
Twenty-three novel BRCA1 and BRCA2 sequence alterations in breast and/or ovarian cancer families in Southern Germany.德国南部乳腺癌和/或卵巢癌家族中23种新的BRCA1和BRCA2基因序列改变
Hum Mutat. 2003 Sep;22(3):259. doi: 10.1002/humu.9174.
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Cancer risk assessment at the atomic level.原子水平的癌症风险评估。
Cancer Res. 2006 Feb 15;66(4):1897-9. doi: 10.1158/0008-5472.CAN-05-3034.
7
Preventive surgery is associated with reduced cancer risk and mortality in women with BRCA1 and BRCA2 mutations.预防性手术与携带BRCA1和BRCA2基因突变的女性患癌风险降低及死亡率降低相关。
LDI Issue Brief. 2010 Oct-Nov;16(2):1-4.
8
Heterogeneous prevalence of recurrent BRCA1 and BRCA2 mutations in Spain according to the geographical area: implications for genetic testing.西班牙不同地区复发性 BRCA1 和 BRCA2 突变的异质性流行率：对基因检测的影响。
Fam Cancer. 2010 Jun;9(2):187-91. doi: 10.1007/s10689-009-9301-5.
9
BRCA1 and BRCA2 have a limited role in familial prostate cancer.BRCA1和BRCA2在家族性前列腺癌中作用有限。
Cancer Res. 2000 Mar 1;60(5):1371-5.
10
Germ-line mutations in BRCA1 or BRCA2 in the normal breast are associated with altered expression of estrogen-responsive proteins and the predominance of progesterone receptor A.正常乳腺中BRCA1或BRCA2的种系突变与雌激素反应蛋白表达改变及孕激素受体A占优势有关。
Genes Chromosomes Cancer. 2004 Mar;39(3):236-48. doi: 10.1002/gcc.10321.

引用本文的文献

1
Mutational spectrum of DNA damage and mismatch repair genes in prostate cancer.前列腺癌中DNA损伤和错配修复基因的突变谱。
Front Genet. 2023 Sep 4;14:1231536. doi: 10.3389/fgene.2023.1231536. eCollection 2023.
2
Prevalence of Germline Variants in Ashkenazi and Non-Ashkenazi Prostate Cancer Populations: A Systematic Review and Meta-Analysis.德系犹太人和非德系犹太人前列腺癌人群中胚系变异的患病率：一项系统评价和荟萃分析
Cancers (Basel). 2023 Jan 2;15(1):306. doi: 10.3390/cancers15010306.
3
Next-generation sequencing of BRCA1 and BRCA2 genes in Moroccan prostate cancer patients with positive family history.对有阳性家族史的摩洛哥前列腺癌患者的 BRCA1 和 BRCA2 基因进行下一代测序。
PLoS One. 2021 Jul 9;16(7):e0254101. doi: 10.1371/journal.pone.0254101. eCollection 2021.
4
Germline Sequencing DNA Repair Genes in 5545 Men With Aggressive and Nonaggressive Prostate Cancer.对 5545 名患有侵袭性和非侵袭性前列腺癌的男性进行种系 DNA 修复基因测序。
J Natl Cancer Inst. 2021 May 4;113(5):616-625. doi: 10.1093/jnci/djaa132.
5
Inherited DNA Repair Gene Mutations in Men with Lethal Prostate Cancer.遗传性 DNA 修复基因突变与致命性前列腺癌男性患者。
Genes (Basel). 2020 Mar 14;11(3):314. doi: 10.3390/genes11030314.
6
BRCA2 gene mutation and prostate cancer risk. Comprehensive review and update.BRCA2基因突变与前列腺癌风险。全面综述与更新。
Saudi Med J. 2020 Jan;41(1):9-17. doi: 10.15537/smj.2020.1.24759.
7
PALB2 variants in hereditary and unselected Finnish prostate cancer cases.芬兰遗传性及非选择性前列腺癌病例中的PALB2基因变异
J Negat Results Biomed. 2009 Dec 15;8:12. doi: 10.1186/1477-5751-8-12.
8
Selected aspects of inherited susceptibility to prostate cancer and tumours of different site of origin.前列腺癌及不同起源部位肿瘤的遗传性易感性的选定方面。
Hered Cancer Clin Pract. 2007 Sep 15;5(3):164-79. doi: 10.1186/1897-4287-5-3-164.

BRCA1 and BRCA2 mutations have no major role in predisposition to prostate cancer in Finland.

作者信息

Ikonen T, Matikainen M P, Syrjäkoski K, Mononen N, Koivisto P A, Rökman A, Seppälä E H, Kallioniemi O-P, Tammela T L J, Schleutker J

机构信息

Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere and Tampere University Hospital, Finland.

出版信息

J Med Genet. 2003 Aug;40(8):e98. doi: 10.1136/jmg.40.8.e98.

DOI:10.1136/jmg.40.8.e98
PMID:12920090
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1735545/
Abstract
摘要