Tentschert S, Greisenegger S, Wimmer R, Lang W, Lalouschek W
Clinical Department of Clinical Neurology, University Clinic of Neurology, University of Vienna, Austria.
Stroke. 2003 Sep;34(9):2114-9. doi: 10.1161/01.STR.0000087361.60511.E7. Epub 2003 Aug 14.
Data regarding hereditary influences on stroke remain controversial. We investigated possible associations of a family history of stroke with clinical parameters in a large cohort of well-documented patients with ischemic cerebrovascular events, with special reference to sex-specific differences.
We analyzed the association between a maternal and/or paternal history of stroke and clinical parameters in 1564 patients with known maternal and paternal history of stroke and suffering from ischemic stroke or transient ischemic attack within the Vienna Stroke Registry.
Patients with a maternal history of stroke were significantly more often female (54%) than those without (44%; P=0.003). Hypertension was more prevalent in female patients with than in those without a maternal history of stroke (87% versus 74%; P=0.001). These associations remained significant after multivariate adjustment (adjusted odds ratio, 1.9; 95% CI, 1.1 to 3.5; P=0.024). Of those female patients with an echocardiogram (n=225), those with a maternal history of stroke more often had left ventricular hypertrophy (48%) than those without (20%) (adjusted odds ratio, 3.6; 95% CI, 1.5 to 8.2; P=0.003). In contrast, hypertension was equally prevalent in male patients with or without a maternal history of stroke (75% versus 74%; P=0.754). We found no significant associations of clinical parameters with a paternal history of stroke.
Our results indicate a sex-specific relationship between a maternal history of stroke and the prevalence of hypertension and left ventricular hypertrophy in female patients with ischemic cerebrovascular events.
关于遗传因素对中风影响的数据仍存在争议。我们在一大群有详细记录的缺血性脑血管事件患者中，研究了中风家族史与临床参数之间可能存在的关联，并特别关注了性别差异。
我们分析了维也纳中风登记处中1564例已知父母中风史且患有缺血性中风或短暂性脑缺血发作的患者，其父母中风史与临床参数之间的关联。
有母亲中风史的患者中女性比例（54%）显著高于无母亲中风史的患者（44%；P=0.003）。有母亲中风史的女性患者高血压患病率高于无母亲中风史的女性患者（87%对74%；P=0.001）。多变量调整后，这些关联仍然显著（调整后的优势比为1.9；95%可信区间为1.1至3.5；P=0.024）。在接受超声心动图检查的女性患者（n=225）中，有母亲中风史的患者左心室肥厚的比例（48%）高于无母亲中风史的患者（20%）（调整后的优势比为3.6；95%可信区间为1.5至8.2；P=0.003）。相比之下，有或无母亲中风史的男性患者高血压患病率相当（75%对74%；P=0.754）。我们发现临床参数与父亲中风史之间无显著关联。
我们的结果表明，在患有缺血性脑血管事件的女性患者中，母亲中风史与高血压患病率及左心室肥厚之间存在性别特异性关系。
