Saruc Murat, Sertdemir Aysen, Turkel Nurten, Tuzcuoglu Isil, Ozden Nuri, Yuceyar Hakan
Department of Gastroenterology, Endoscopy Unit, Celal Bayar University, Manisa, Turkey.
Gastroenterol Nurs. 2003 Jul-Aug;26(4):164-7. doi: 10.1097/00001610-200307000-00007.
Upper gastrointestinal endoscopy can be performed without intravenous sedation but the evidence suggests most patients and endoscopists prefer some form of premedication. Intravenous diazepam or midazolam are used by the majority of endoscopists in the United States, though it is not common practice in Turkey where this study was conducted. This study aimed to evaluate the efficacy and safety of midazolam in performing upper gastrointestinal endoscopy. A total of 352 patients undergoing upper gastrointestinal endoscopy were sedated with midazolam given as a bolus injection over 5 seconds. Ages of the patients ranged between 16 and 79 years (average: 41.6 +/- 12.7 years). The course of endoscopy, anterograde memory, degree of cooperation, degree of sedation, side effects, and acceptability of further intervention were evaluated by a questionnaire given to the patients and endoscopists.
上消化道内镜检查可以在不使用静脉镇静剂的情况下进行，但证据表明大多数患者和内镜医师更喜欢某种形式的术前用药。在美国，大多数内镜医师使用静脉注射地西泮或咪达唑仑，不过在进行这项研究的土耳其，这种做法并不常见。本研究旨在评估咪达唑仑在上消化道内镜检查中的有效性和安全性。共有352例接受上消化道内镜检查的患者通过在5秒内推注咪达唑仑进行镇静。患者年龄在16至79岁之间（平均：41.6±12.7岁）。通过向患者和内镜医师发放问卷，评估内镜检查过程、顺行性记忆、合作程度、镇静程度、副作用以及进一步干预的可接受性。
