Fernandes Sara Regina Castanheira, Homa Marcia Noriko de Oliveira, Igarashi Aghata, Salles Andréa Luiza Mendes, Jaloretto Ana Paula, Freitas Maria Silvia, Nogueira Paulo Cesar Koch
Department of Pediatrics, Faculdade de Ciências Médicas de Santos, Santos, Brazil.
Sao Paulo Med J. 2003 May 5;121(3):125-7. doi: 10.1590/s1516-31802003000300008. Epub 2003 Aug 8.
Tuberculosis is an important public health issue. The Brazilian government reported 78,460 new cases in 1999. Miliary tuberculosis is a severe form of this disease.
To report on an uncommon clinical presentation of miliary tuberculosis in a child.
A 5-year old boy presented in the emergency room with fatigue and weight loss. He had had Staphylococcus aureus pneumonia 7 months before. Chest radiography revealed lobar consolidation and miliary pattern associated with small cavities in both upper lobes. Antibiotic therapy was started. The sputum was positive for acid-fast bacilli and hence the treatment recommended for tuberculosis (rifampicin, isoniazid [INH], pyrazinamide) was started. The patient was treated for 9 months and at the end of the follow-up period he had made a complete clinical recovery.
Although in some particular cases sputum can be positive for acid-fast bacilli in children, limitations to the sputum test have forced pediatricians to base tuberculosis diagnosis on epidemiological data, clinical findings and radiographic pattern. In this particular case, we hypothesize that the sputum bacillus test was positive because bacilli grew inside residual pneumatoceles that were produced during previous pneumonia.
结核病是一个重要的公共卫生问题。巴西政府报告1999年有78460例新病例。粟粒性肺结核是这种疾病的一种严重形式。
报告一名儿童粟粒性肺结核不常见的临床表现。
一名5岁男孩因疲劳和体重减轻到急诊室就诊。他7个月前曾患金黄色葡萄球菌肺炎。胸部X线检查显示大叶实变以及两上叶粟粒样改变并伴有小空洞。开始使用抗生素治疗。痰涂片抗酸杆菌阳性,因此开始采用推荐的抗结核治疗方案(利福平、异烟肼、吡嗪酰胺)。该患者接受了9个月的治疗,随访结束时临床完全康复。
尽管在某些特殊情况下儿童痰涂片抗酸杆菌可为阳性,但痰检的局限性迫使儿科医生根据流行病学数据、临床表现和影像学特征来诊断结核病。在这个特殊病例中,我们推测痰菌检测呈阳性是因为杆菌生长于先前肺炎期间形成的残留肺气囊内。