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神经管缺陷的病因：叶酸的作用。

The etiology of neural tube defects: the role of folic acid.

作者信息

McLone David G

机构信息

Division of Neurological Surgery, The Children's Memorial Hospital, 2300 Children's Plaza, Chicago, IL 60614, USA.

出版信息

Childs Nerv Syst. 2003 Aug;19(7-8):537-9. doi: 10.1007/s00381-003-0793-2. Epub 2003 Aug 12.

DOI:10.1007/s00381-003-0793-2
PMID:12920544
Abstract

DISCUSSION

While the cause of neural tube defects in humans is considered to be multifactorial, it is apparent that folic acid can prevent 70% of open neural tube defects. Even in laboratory animals with known genetic defects, folic acid can prevent the genetic expression.

CONCLUSION

While some of the metabolic pathways for folic acid are known, the true effects of folic acid on closure of the neural tube have yet to be discovered.

摘要

讨论

虽然人类神经管缺陷的病因被认为是多因素的，但显然叶酸可以预防70%的开放性神经管缺陷。即使在具有已知遗传缺陷的实验动物中，叶酸也可以阻止基因表达。

结论

虽然叶酸的一些代谢途径是已知的，但叶酸对神经管闭合的真正作用尚未被发现。

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本文引用的文献

1
Knowledge and use of folic acid by women of childbearing age--United States, 1995 and 1998.美国1995年及1998年育龄妇女对叶酸的知晓与使用情况
MMWR Morb Mortal Wkly Rep. 1999 Apr 30;48(16):325-7.
2
Drug and environmental factors associated with adverse pregnancy outcomes. Part III: Folic acid: pharmacology, therapeutic recommendations, and economics.与不良妊娠结局相关的药物和环境因素。第三部分：叶酸：药理学、治疗建议及经济学
Ann Pharmacother. 1998 Oct;32(10):1087-95. doi: 10.1345/aph.17427.
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Drug and environmental factors associated with adverse pregnancy outcomes. Part I: Antiepileptic drugs, contraceptives, smoking, and folate.
Ann Pharmacother. 1998 Jul-Aug;32(7-8):802-17. doi: 10.1345/aph.17297.
4
Risk of neural tube defect-affected pregnancies among obese women.肥胖女性中受神经管缺陷影响的妊娠风险。
JAMA. 1996 Apr 10;275(14):1093-6. doi: 10.1001/jama.1996.03530380035028.
5
Prepregnant weight in relation to risk of neural tube defects.孕前体重与神经管缺陷风险的关系。
JAMA. 1996 Apr 10;275(14):1089-92. doi: 10.1001/jama.1996.03530380031027.
6
Use of folic acid for prevention of spina bifida and other neural tube defects--1983-1991.1983 - 1991年期间叶酸用于预防脊柱裂和其他神经管缺陷的情况
MMWR Morb Mortal Wkly Rep. 1991 Aug 2;40(30):513-6.
7
Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation.受孕前补充维生素预防神经管缺陷的首次发生。
N Engl J Med. 1992 Dec 24;327(26):1832-5. doi: 10.1056/NEJM199212243272602.