通过细针穿刺诊断艾滋病患者同时合并巨细胞病毒感染和甲状腺卡波西肉瘤。病例报告及首次对两种病变同时出现的细胞学描述。
Simultaneous cytomegalovirus infection and Kaposi's sarcoma of the thyroid diagnosed by fine needle aspiration in an AIDS patient. A case report and first cytologic description of the two entities occurring together.
作者信息
Zhang Xinmin, el-Sahrigy Dina, Elhosseiny Abdelmonem, Melamed Myron R
机构信息
Department of Pathology, New York Medical College, Westchester Medical Center, Valhalla, New York, USA.
出版信息
Acta Cytol. 2003 Jul-Aug;47(4):645-8. doi: 10.1159/000326582.
BACKGROUND
Cytomegalovirus (CMV) infection and Kaposi's sarcoma (KS) are common in AIDS patients but rarely involve the thyroid, and coexistence of these two entities in that organ has not yet been described before.
CASE
A 41-year-old female AIDS patient presented with a 2 x 1-cm, well-demarcated, rubbery mass in the right side of the thyroid. On fine needle aspiration (FNA), spindle cells were retrieved singly or in small, loose clusters; they had bland, fusiform to cigar-shaped nuclei; inconspicuous nucleoli; delicate cytoplasmic vacuoles; cytoplasmic hyaline drops; and hemosiderin granules. A single endothelial cell showed an enlarged nucleus with a basophilic intranuclear inclusion and periinclusional halo.
CONCLUSION
This is the first reported case of an AIDS patient with KS and CMV infection simultaneously involving the thyroid diagnosed by FNA.
背景
巨细胞病毒（CMV）感染和卡波西肉瘤（KS）在艾滋病患者中很常见，但很少累及甲状腺，此前尚未有这两种病变在该器官共存的报道。
病例
一名41岁女性艾滋病患者，甲状腺右侧有一个2×1厘米、边界清晰、质地坚韧的肿块。细针穿刺活检（FNA）显示，梭形细胞单个或呈小而松散的簇状出现；细胞核形态温和，呈梭形至雪茄形；核仁不明显；胞质内有细小空泡；有胞质透明滴和含铁血黄素颗粒。单个内皮细胞显示细胞核增大，有嗜碱性核内包涵体和包涵体周围晕。
结论
这是首例经FNA诊断的艾滋病患者同时患有KS和CMV感染且累及甲状腺的病例。
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