[重组人表皮生长因子对深Ⅱ度烧伤创面长期影响的临床观察]
[Clinical observation of the long-term effects of rhEGF on deep partial-thickness burn wounds].
作者信息
Wang Guang-yi, Xia Zhao-fan, Zhu Shi-hui, Tang Hong-tai, Huan Jing-ning, Chen Yu-lin, Ge Sheng-de
机构信息
Department of Burns, Changhai Hospital, The Second Military Medical University, Shanghai, 200433, PR China.
出版信息
Zhonghua Shao Shang Za Zhi. 2003 Jun;19(3):167-8.
OBJECTIVE
To evaluate the safety and long-term effect of recombinant human epithelial growth factor (rhEGF) on deep partial-thickness burn wounds.
METHODS
Thirty-seven burn patients were enrolled in this study and were observed by randomized, double-blinded and placebo-controlled protocol. An area of deep partial-thickness burn wounds from each patient was divided into control (C) and treatment (T) portions. The wound in C was treated with normal saline while that in T with rhEGF. The patients were followed-up for 1 and 4 years after wound healing. The healed wounds were evaluated by modified Vancouver scar scale in terms of scar index (SI).
RESULTS
1 year after wound healing, it was found that the SI in T group (7.19 +/- 1.67) was obviously lower than that in C group (8.92 +/- 1.78, P < 0.01). The SI in T group (6.12 +/- 1.54) was still evidently lower than that in C group (8.09 +/- 1.81, P < 0.01) four years after wound healing. There were no signs of development of tumor or cancer in all the tested burn wound areas.
CONCLUSION
External application of rhEGF might be beneficial to the healing quality of deep partial-thickness burn wound with less scar formation and better long-term effects, and it is safe.
目的
评估重组人表皮生长因子（rhEGF）对深Ⅱ度烧伤创面的安全性及长期疗效。
方法
37例烧伤患者纳入本研究，采用随机、双盲、安慰剂对照方案进行观察。将每位患者深Ⅱ度烧伤创面分为对照（C）区和治疗（T）区。C区创面用生理盐水处理，T区创面用rhEGF处理。创面愈合后对患者进行1年和4年随访。采用改良温哥华瘢痕量表根据瘢痕指数（SI）对愈合创面进行评估。
结果
创面愈合1年后，发现T组SI（7.19±1.67）明显低于C组（8.92±1.78，P<0.01）。创面愈合4年后，T组SI（6.12±1.54）仍明显低于C组（8.09±1.81，P<0.01）。所有受试烧伤创面区域均无肿瘤或癌症发生迹象。
结论
外用rhEGF可能有利于深Ⅱ度烧伤创面的愈合质量，瘢痕形成较少且长期效果较好，并且是安全的。
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