Liao Yi, Guo Li, Ding Er-ying
Department of Burn and Plastic Surgery, Affiliated Hospital, Luzhou Medical College, Luzhou, Sichuan, P. R. China, 646000.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2003 Jul;17(4):301-2.
To explore an optimal method of recombinant human epidermal growth factor(rhEGF) application on the burn wounds of superficial II degree and profound II degree for accelerating its healing.
There were 180 burn wounds in 60 patients with the self-corresponding wound of the same degree as controls. The wounds of all patients were divided three regions(A, B, C). The wounds were treated once a day with 1% SD-Ag in region A as controls, with rhEGF(40 U/cm2) in region B, and with a combination of rhEGF(40 U/cm2) and Su Yu Ping (5 g) in region C. The wound healing time was recorded and compared.
In regions A, B and C, the healing time of superficial II degree wound was (13.20 +/- 2.40) days, (10.20 +/- 2.20) days and (8.72 +/- 2.31) days (P < 0.01); that of profound II degree wound was (20.10 +/- 3.40) days, (17.20 +/- 3.12) days and (15.10 +/- 3.81) days respectively (P < 0.01, P < 0.05). The healed wound of profound II degree was elastic and tough in regions B and C, while that was not elastic and tough, and congestive in region A.
The above results indicate that rhEGF can enhance burn wound healing markedly and that a combination rhEGF and Su Yu Ping has more significant effect than rhEGF alone and is recommended for clinical application.
探索重组人表皮生长因子（rhEGF）用于浅Ⅱ度和深Ⅱ度烧伤创面以加速愈合的最佳方法。
60例患者共180个烧伤创面，设与其自身相应程度的创面为对照。将所有患者的创面分为三个区域（A、B、C）。A区创面每日用1%磺胺嘧啶银处理作为对照，B区创面用rhEGF（40 U/cm²）处理，C区创面用rhEGF（40 U/cm²）与苏愈平（5 g）联合处理。记录并比较创面愈合时间。
A、B、C区浅Ⅱ度创面愈合时间分别为（13.20±2.40）天、（10.20±2.20）天和（8.72±2.31）天（P<0.01）；深Ⅱ度创面愈合时间分别为（20.10±3.40）天、（17.20±3.12）天和（15.10±3.81）天（P<0.01，P<0.05）。B区和C区深Ⅱ度创面愈合后弹性好、质地坚韧，而A区愈合后无弹性、质地不坚韧且充血。
上述结果表明，rhEGF能显著促进烧伤创面愈合，rhEGF与苏愈平联合应用效果优于单纯使用rhEGF，建议临床应用。
