Li Tian-zeng, Xu Ying-bin, Hu Xiao-gen, Shen Rui, Peng Xiao-dong, Wu Wei-jiang, Luo Lan, Dai Xin-ming, Zou Yong-tong, Qi Shao-hai, Wu Li-ping, Xie Ju-lin, Deng Xiao-xin, Chen E, Zhang Hui-Zhen
Department of Burns, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, P.R. China.
Zhonghua Shao Shang Za Zhi. 2005 Aug;21(4):266-9.
To investigate the effect of negative charge aerosol (NCA) on the treatment of burn wound.
Patients with superficial or deep partial thickness burn only were enrolled in the study, and they were randomly divided into trial group (T, including 180 cases of superficial thickness burn and 100 cases of deep partial thickness burn), control group (C, including 30 cases with superficial thickness burn and 30 with deep partial thickness burn), and self control group (SC, including 10 cases with superficial thickness burn and 10 with deep partial thickness burn). The patients in T and SC groups were treated with NCA for 1.5 hours, 1-2 times a day, from 6 postburn hour (PBH) to 2 postburn day (PBD), while those in C group received conventional treatment. For those in SC group, some of the wounds were covered with sterile schissel, while other wounds without schissel covering. The general changes in the wounds during NCA treatment were observed, and bacterial culture before and after NCA treatment was performed. The healing time was recorded and the blood biochemical parameters were determined. Rat model with deep partial thickness scald was established, and the rats were also divided into T and C groups, and received treatment as in human. Tissue samples were harvested from the wounds of rats in the 2 groups before and 1, 2, 3 weeks after treatment for pathological examination.
There was no infection and little exudation in the patients in T group. No bacteria were found in the wound before and after NCA treatment. The healing time of the wounds of patients with superficial and deep partial thickness burn in T group was 6.3 +/- 1.6 d and 15.1 +/- 3.1 d, respectively, which was obviously shorter than those in C group (11.3 +/- 1.4 d and 21.2 +/- 1.4 d, P < 0.01). In SC group, the healing time of those with sterile schissel coverage was also significantly shorter than those without covering (P < 0.01). There was no obvious change in the liver and kidney functions and blood biochemical parameters among the patients. Pathological examination showed that the skin structure was almost recovered in the rats in T group 3 weeks after treatment, while those in C group was not.
Negative charge aerosol is safe and effective in promoting wound healing of the patients with partial thickness burns.
探讨负电荷气溶胶（NCA）对烧伤创面治疗的效果。
仅纳入浅Ⅱ度或深Ⅱ度烧伤患者进行研究，将其随机分为试验组（T组，包括浅Ⅱ度烧伤180例和深Ⅱ度烧伤100例）、对照组（C组，包括浅Ⅱ度烧伤30例和深Ⅱ度烧伤30例）和自身对照组（SC组，包括浅Ⅱ度烧伤10例和深Ⅱ度烧伤10例）。T组和SC组患者于伤后6小时（PBH）至伤后2天（PBD）接受NCA治疗，每天1 - 2次，每次1.5小时，C组患者接受常规治疗。SC组患者部分创面覆盖无菌凡士林纱布，部分创面未覆盖。观察NCA治疗期间创面的一般变化，进行NCA治疗前后创面细菌培养。记录愈合时间并测定血液生化参数。建立深Ⅱ度烫伤大鼠模型，大鼠也分为T组和C组，并按人体治疗方法进行处理。在治疗前及治疗后1、2、3周采集两组大鼠创面组织样本进行病理检查。
T组患者创面无感染且渗出少。NCA治疗前后创面均未检出细菌。T组浅Ⅱ度和深Ⅱ度烧伤患者创面愈合时间分别为6.3±1.6天和15.1±3.1天，明显短于C组（11.3±1.4天和21.2±1.4天，P<0.01）。SC组中，覆盖无菌凡士林纱布的创面愈合时间也显著短于未覆盖者（P<0.01）。患者的肝肾功能及血液生化参数无明显变化。病理检查显示，T组大鼠治疗3周后皮肤结构基本恢复，而C组未恢复。
负电荷气溶胶促进浅Ⅱ度烧伤患者创面愈合安全有效。
