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[Preclinical trials of polyplatillen, the antitumor activity of a complex platinum compound with DNA on a leukemia P388 model in a HEp-2 cell culture (1)].

作者信息

Shalimov S A, Trokhimenko E P, Dziublik I V, Keĭsevich L V, Volchenskova I I, Kogut G I, Glukhen'kaia G T

出版信息

Lik Sprava. 1992 Nov-Dec(11-12):114-7.

PMID:1292205
Abstract

The authors studied the antitumour activity of a new complex platinum compound (DDP-DNA) in mice with leukemia P-388 and in cell culture. DDP-DNA was introduced intraperitoneally 24 hours after inoculation of 2 x 10(6) tumour cells. It was established that by its antitumour activity DDP-DNA was not inferior then DDP. The antiproliferative activity of nontoxic doses of the preparation in cell culture has been shown.

摘要

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