健康同性恋个体对乙型肝炎疫苗的反应：回顾性病例对照研究。

Response to hepatitis-B vaccination in healthy homosexual individuals: retrospective case control study.

作者信息

Das Satyajit, Brassington Mary, Drake Susan M, Boxall Elizabeth

机构信息

Department of Genito-Urinary and HIV Medicine, Whittall Street Clinic, Whittall Street, Birmingham B4 6DH, UK.

出版信息

Vaccine. 2003 Sep 8;21(25-26):3701-5. doi: 10.1016/s0264-410x(03)00392-x.

DOI:10.1016/s0264-410x(03)00392-x

PMID:12922100

Abstract

The aim of the study was to compare the responses of homosexual men (HM) receiving a standard course of recombinant hepatitis B vaccine with those of healthcare workers vaccinated in the same hospital over the same period. Boosters for inadequate responders and repeat courses for non-responders were given. Forty of 61 (75.4%) of HM completing full follow-up were successfully vaccinated, compared with 128 of 129 (99.2%) female and 94 of 96 (97.9%) male health care workers (P<0.001). The response to hepatitis-B vaccination in healthy homosexual men is poor and significantly lower than healthcare workers vaccinated and followed up according to the same protocol.

摘要

该研究的目的是比较接受标准疗程重组乙肝疫苗的男同性恋者（HM）与同期在同一家医院接种疫苗的医护人员的反应。对无足够反应者给予加强针，对无反应者给予重复疗程。完成全面随访的61名HM中有40名（75.4%）成功接种疫苗，相比之下，129名女性医护人员中有128名（99.2%），96名男性医护人员中有94名（97.9%）（P<0.001）。健康男同性恋者对乙肝疫苗的反应较差，明显低于按照相同方案接种并随访的医护人员。