[异丙肾上腺素、普萘洛尔与大鼠唾液腺的体内磷代谢]

[Isoprenaline, propranolol and in vivo phosphorus metabolism of the rat salivary gland].

作者信息

Rochus L, Reuse J J

出版信息

C R Seances Soc Biol Fil. 1975;169(3):737-41.

Abstract

Chronic treatment with isoprenaline causes hypersecretion and a marked enlargement of submaxillary glands. Isoprenaline, given to normal rats or treated animals with hypertrophied salivary glands, increases the incorporation of 32P in tissue inorganic and organic phosphates and phospholipids. Propranolol given alone is inactive on phosphorus metabolism, but inhibits the effect of isoprenaline. The phospholipid effect is probably related to the increase of membranes in hypertrophied acinar cells; a correlation with the hypersecretion induced by isoprenaline needs further study. The results show that in experimental sialadenosis and hypersialorrhea induced by isoprenaline in the whole rat stimulation of glandular beta-adrenoreceptors and phosphorus metabolism are involved.

摘要

用异丙肾上腺素进行慢性治疗会导致颌下腺分泌过多和显著肿大。给正常大鼠或唾液腺肥大的实验动物注射异丙肾上腺素，会增加32P在组织无机磷酸盐、有机磷酸盐和磷脂中的掺入。单独给予普萘洛尔对磷代谢无活性，但能抑制异丙肾上腺素的作用。磷脂效应可能与肥大腺泡细胞中膜的增加有关；与异丙肾上腺素诱导的分泌过多之间的相关性需要进一步研究。结果表明，在异丙肾上腺素诱导的大鼠实验性涎腺肿大和唾液分泌过多中，涉及腺β-肾上腺素能受体的刺激和磷代谢。