Sul Hae Joung, Kang Dae young
Department of Pathology, Konyang University College of Medicine, Daejeon, Korea.
J Korean Med Sci. 2003 Aug;18(4):618-20. doi: 10.3346/jkms.2003.18.4.618.
Neuroblastomas are derived from the neural crest ectoderm, and are the most common solid abdominal masses of infancy. Congenital neuroblastoma, however, is rare. We report a rare case of congenital neuroblastoma with multiple metastases found at autopsy, performed at 2 days after birth. He was born by cesarian section and weighed 2,350 g. His respiration was weak and abdomen was distended. The patient died 2 days after birth. Postmortem examination revealed a relatively well demarcated ovoid mass, in the left adrenal, with necrosis and hemorrhage. Multiple small metastatic tumor nodules in the liver, lung, kidney, brain, rib, thyroid glands, and spleen, were noted. The histopathological pictures confirmed the diagnosis of neuroblastoma of the adrenal with multiple metastasis.
神经母细胞瘤起源于神经嵴外胚层，是婴儿期最常见的腹部实体肿块。然而，先天性神经母细胞瘤却很罕见。我们报告一例罕见的先天性神经母细胞瘤病例，该病例在出生后2天进行尸检时发现有多处转移。患儿通过剖宫产出生，体重2350克。呼吸微弱，腹部膨隆。患儿出生后2天死亡。尸检发现左肾上腺有一个边界相对清晰的卵圆形肿块，伴有坏死和出血。还注意到肝脏、肺、肾、脑、肋骨、甲状腺和脾脏有多个小的转移瘤结节。组织病理学图像证实为肾上腺神经母细胞瘤伴多处转移。
