Kim Yoonjung, Suh Yeon Lim, Sung Changohk, Hong Seung Chyul
Department of Diagnostic Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
J Korean Med Sci. 2003 Aug;18(4):625-9. doi: 10.3346/jkms.2003.18.4.625.
Gliofibroma is a rare astrocytic tumor, composed of a glial component ranging from benign to high grade of malignancy and a consistently benign mesenchymal component. Its exact biological behavior is not fully known. In addition, histogenesis and prognostic factors are also still debatable. We herein present a rare case of gliofibroma in a 25-yr-old male with seizure. A computed tomographic scan of the brain showed a 1.5 cm-sized, enhancing mass with calcification. Histologically, the tumor consisted of glial fibrillary acidic protein (GFAP)-positive glial cells admixed with a mesenchymal component and extensive collagen lay down. The glial cells displayed variable cellularity, but without mitosis or necrosis. Since the MIB-1 labeling index was up to 35.8% in the cellular areas of the glial component, it could be considered to be a predictor of worse prognosis.
胶质纤维瘤是一种罕见的星形细胞瘤，由从良性到高度恶性的神经胶质成分和始终为良性的间充质成分组成。其确切的生物学行为尚不完全清楚。此外，组织发生和预后因素也仍有争议。我们在此报告一例25岁男性患有癫痫的罕见胶质纤维瘤病例。脑部计算机断层扫描显示一个1.5厘米大小、有强化且伴有钙化的肿块。组织学上，肿瘤由胶质纤维酸性蛋白（GFAP）阳性的神经胶质细胞与间充质成分混合，并有大量胶原沉积。神经胶质细胞显示出不同的细胞密度，但无有丝分裂或坏死。由于在神经胶质成分的细胞区域中MIB-1标记指数高达35.8%，因此可认为它是预后较差的一个预测指标。
