Prayson R A
Department of Anatomic Pathology, Cleveland Clinic Foundation, OH 44195, USA.
Hum Pathol. 1996 Jun;27(6):610-3. doi: 10.1016/s0046-8177(96)90171-9.
Gliofibromas are rarely encountered astrocytic neoplasms characterized by an admixture of astrocytic and fibroblastic cell components. The exact nature of these rare tumors are still a matter of considerable debate. This article reports a case of gliofibroma occurring in a 3-month-old boy. The astrocytic component of the tumor stained diffusely positive for glial fibrillary acidic protein (GFAP) and S-100 protein. Prominent reticulin staining was observed within the fibroblastic component of the tumor. The MIB1 labeling index (positive number of tumor cells divided by total tumor cells counted X 100) was low (0.9), supporting the general slow growth of these tumors. Immunohistochemical staining with antibody against p53 protein was negative. Gliofibromas seem to be a low-grade variant of an astrocytoma that shares many features with other desmoplastic astrocytic neoplasms (desmoplastic infantile astrocytoma, desmoplastic infantile ganglioglioma) including a generally favorable prognosis.
胶质纤维瘤是罕见的星形细胞瘤，其特征是星形细胞和成纤维细胞成分混合。这些罕见肿瘤的确切性质仍存在相当大的争议。本文报告了一例发生在一名3个月大男婴身上的胶质纤维瘤。肿瘤的星形细胞成分对胶质纤维酸性蛋白（GFAP）和S-100蛋白呈弥漫性阳性染色。在肿瘤的成纤维细胞成分中观察到明显的网状纤维染色。MIB1标记指数（肿瘤细胞阳性数除以计数的肿瘤细胞总数×100）较低（0.9），支持这些肿瘤通常生长缓慢的观点。用抗p53蛋白抗体进行免疫组化染色为阴性。胶质纤维瘤似乎是星形细胞瘤的一种低级别变体，与其他促纤维增生性星形细胞瘤（促纤维增生性婴儿星形细胞瘤、促纤维增生性婴儿节细胞胶质瘤）有许多共同特征，包括总体预后良好。
