Rawson Robert B
Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.
Nat Rev Mol Cell Biol. 2003 Aug;4(8):631-40. doi: 10.1038/nrm1174.
Animal cells coordinate lipid homeostasis by end-product feedback regulation of transcription. The control occurs through the proteolytic release of transcriptionally active sterol regulatory element binding proteins (SREBPs) from intracellular membranes. This feedback system has unexpected features that are found in all cells. Here, we consider recently discovered components of the regulatory machinery that govern SREBP processing, as well as studies in Drosophila that indicate an ancient role for the SREBP pathway in integrating membrane composition and lipid biosynthesis.
动物细胞通过转录的终产物反馈调节来协调脂质稳态。这种调控是通过转录活性固醇调节元件结合蛋白（SREBPs）从细胞内膜的蛋白水解释放来实现的。这种反馈系统具有在所有细胞中都能发现的意外特征。在这里，我们考虑最近发现的控制SREBP加工的调节机制的组成部分，以及在果蝇中的研究，这些研究表明SREBP途径在整合膜组成和脂质生物合成中具有古老的作用。
