Wu Kangze, Lin Feizhuan
Department of Hepatobiliary Surgery, Shaoxing People's Hospital, Shaoxing, People's Republic of China.
J Hepatocell Carcinoma. 2024 Feb 14;11:327-346. doi: 10.2147/JHC.S450423. eCollection 2024.
Hepatocellular carcinoma (HCC) stands as a severe malignant tumor with a profound impact on overall health, often accompanied by an unfavorable prognosis. Despite some advancements in the diagnosis and treatment of this disease, improving the prognosis of HCC remains a formidable challenge. It is noteworthy that lipid metabolism plays a pivotal role in the onset, development, and progression of tumor cells. Existing research indicates the potential application of targeting lipid metabolism in the treatment of HCC. This review aims to thoroughly explore the alterations in lipid metabolism in HCC, offering a detailed account of the potential advantages associated with innovative therapeutic strategies targeting lipid metabolism. Targeting lipid metabolism holds promise for potentially enhancing the prognosis of HCC.
肝细胞癌(HCC)是一种严重的恶性肿瘤,对整体健康有深远影响,通常预后不佳。尽管该疾病的诊断和治疗取得了一些进展,但改善HCC的预后仍然是一项艰巨的挑战。值得注意的是,脂质代谢在肿瘤细胞的发生、发展和进展中起着关键作用。现有研究表明靶向脂质代谢在HCC治疗中的潜在应用。本综述旨在深入探讨HCC中脂质代谢的变化,详细阐述针对脂质代谢的创新治疗策略的潜在优势。靶向脂质代谢有望潜在地改善HCC的预后。