Andlauer Wilfried, Stumpf Claudia, Frank Konstanze, Fürst Peter
Institute for Biological Chemistry & Nutrition, University of Hohenheim Stuttgart, Stuttgart, Germany.
Eur J Nutr. 2003 Aug;42(4):217-23. doi: 10.1007/s00394-003-0417-3.
Anthocyanins are receiving renewed attention for their positive health attributes. High intakes and an adequate absorption rate of anthocyanins are necessary for efficient protection, though other dietary agents might influence absorption efficacy. The aim of this study was to investigate intestinal handling of luminally administered cyanidin-3-glucoside in the absence and presence of ethanol in an isolated preparation of luminally and vascularly perfused rat small intestine. A synthetic perfusate free from blood components was used as vascular medium, with a perfluorocarbon as the oxygen carrier. Luminal media consisted of a bicarbonate buffered sodium chloride solution in water or in water/ethanol (95/5), spiked with cyanidin-3-glucoside. Absorption rate of cyanidin-3-glucoside was 4.3% +/- 3.2 (n=5). Ethanol (5 %) had no significant influence on absorption rate (2.9% +/- 1.8, n=5). Irrespective of the presence of ethanol, the majority of the absorbed cyanidin-3-glucoside appeared unchanged, besides some cyanidin-3-glucoside-conjugate.
花青素因其对健康有益的特性而再次受到关注。要实现有效保护，高摄入量和足够的花青素吸收率是必要的，不过其他膳食成分可能会影响吸收效果。本研究的目的是在离体灌注大鼠小肠的制备中，研究在不存在和存在乙醇的情况下，经肠腔给予的矢车菊素-3-葡萄糖苷在肠道中的处理情况。一种不含血液成分的合成灌注液用作血管介质，全氟碳作为氧载体。肠腔介质由水中或水/乙醇（95/5）中的碳酸氢盐缓冲氯化钠溶液组成，并添加矢车菊素-3-葡萄糖苷。矢车菊素-3-葡萄糖苷的吸收率为4.3%±3.2（n = 5）。乙醇（5%）对吸收率没有显著影响（2.9%±1.8，n = 5）。无论乙醇是否存在，除了一些矢车菊素-3-葡萄糖苷共轭物外，大部分吸收的矢车菊素-3-葡萄糖苷似乎未发生变化。
