布洛芬离子导入疗法与连续超声疗法治疗膝骨关节炎的短期疗效比较

Short term efficacy of ibuprofen phonophoresis versus continuous ultrasound therapy in knee osteoarthritis.

作者信息

Kozanoglu Erkan, Basaran Sibel, Guzel Rengin, Guler-Uysal Fusun

机构信息

Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Cukurova Unviersity, Adana, Turkey.

出版信息

Swiss Med Wkly. 2003 Jun 14;133(23-24):333-8. doi: 10.4414/smw.2003.10210.

DOI:10.4414/smw.2003.10210

PMID:12923684

Abstract

AIM OF STUDY

To compare the effectiveness of ibuprofen phonophoresis (PH) with conventional ultrasound (US) therapy in knee osteoarthritis.

METHOD

Sixty patients with a mean age of 59.8 +/- 9.0 years were randomly assigned to PH or US groups. Continuous ultrasonic waves of 1 MHz frequency and 1 watt/cm2 power were applied for 5 minutes to the target knee joint. Acoustic gel without any active pharmacological agent was applied in the US group, whereas cream containing 5% ibuprofen was applied in the PH group for a total treatment period of 10 sessions. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores, pain on passive and active motion, 20 metres walking time, knee range of motion (ROM), and global assessments of disease activity and treatment efficacy by the investigator and by the patients were evaluated before and after therapy. Primary outcome measure of the study was 30% improvement in total WOMAC scores at the end of the study with respective scores at baseline.

RESULTS

At the end of two weeks, 30% improvement in total WOMAC score was observed in 12 (40%) and 14 (46.6%) of patients in the PH and US groups respectively, indicating no significant difference in improvement rates. Pain scores, knee ROM degrees, 20 metres walking time measurements and all global assessment scores also improved significantly in both groups, yet these variables showed no significant differences between the two groups. When treatment efficacy was assessed as satisfaction rates, investigator satisfaction rates were 96.7% and 90%, while patient satisfaction rates were 93.3% and 83.3% in the PH and US groups respectively, suggesting similar satisfaction rates for both treatment methods.

CONCLUSIONS

Both therapeutic modalities were found to be effective and generally well tolerated after 10 therapy sessions. Ibuprofen PH was not superior to conventional ultrasound in patients with knee osteoarthritis.

摘要

研究目的

比较布洛芬离子导入疗法（PH）与传统超声（US）疗法对膝关节骨关节炎的疗效。

方法

60例平均年龄为59.8±9.0岁的患者被随机分为PH组或US组。将频率为1MHz、功率为1瓦/平方厘米的连续超声波施加于目标膝关节5分钟。US组使用不含任何活性药物成分的声学凝胶，而PH组使用含5%布洛芬的乳膏，整个治疗期共10次。在治疗前后评估西安大略和麦克马斯特大学骨关节炎指数（WOMAC）评分、被动和主动运动时的疼痛、20米步行时间、膝关节活动范围（ROM）以及研究者和患者对疾病活动和治疗效果的整体评估。该研究的主要结局指标是在研究结束时总WOMAC评分相对于基线评分有30%的改善。

结果

在两周结束时，PH组和US组分别有12例（40%）和14例（46.6%）患者的总WOMAC评分改善了30%，表明改善率无显著差异。两组的疼痛评分、膝关节ROM度数、20米步行时间测量值以及所有整体评估评分也均有显著改善，但这些变量在两组之间无显著差异。当将治疗效果评估为满意率时，PH组和US组研究者的满意率分别为96.7%和90%，患者的满意率分别为93.3%和83.3%，表明两种治疗方法的满意率相似。