Department of Physical Medicine and Rehabilitation, Cukurova University Faculty of Medicine, Adana, Turkey.
Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Cukurova University Faculty of Medicine, Adana, Turkey.
Rheumatol Int. 2018 Oct;38(10):1927-1932. doi: 10.1007/s00296-018-4099-9. Epub 2018 Jul 12.
The objective of the present study was to compare the effectiveness of gel and cream ibuprofen phonophoresis in patients with knee osteoarthritis. A single-blinded, randomized, comparative design was applied. Patients diagnosed with knee osteoarthritis according to the American College of Rheumatology criteria were included in the study. After obtaining written informed consent, patients were randomized into ibuprofen gel and cream phonophoresis groups. Each patient was treated five sessions per week for 2 weeks (ten sessions). Main outcome measures were 100 mm visual analogue scale (VAS) for pain and the disease-specific questionnaire; Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Sixty-one knee osteoarthritis patients with a mean age of 57.9 ± 9.7 years were included in the study. Baseline VAS and WOMAC scores were similar between gel (n = 30) and cream (n = 31) phonophoresis groups (p > 0.05 for both). Following the treatment, both groups showed improvement compared to baseline measures including VAS pain and WOMAC scores. In the gel phonophoresis group, the improvement in VAS score was higher than that observed in the cream phonophoresis group (p < 0.001). Similarly, the improvement in WOMAC total score was also higher in the gel phonophoresis group (p < 0.001). Ibuprofen phonophoresis is clinically effective in patients with knee osteoarthritis. Phonophoresis using the gel form of ibuprofen is associated with more clinical improvement than that using the cream form of the same molecule.
本研究的目的是比较凝胶和乳膏型布洛芬声透皮治疗膝骨关节炎的疗效。采用单盲、随机、对照设计。符合美国风湿病学会标准的膝骨关节炎患者纳入研究。获得书面知情同意后，患者被随机分为布洛芬凝胶和乳膏声透皮治疗组。每位患者每周治疗 5 次，持续 2 周（共 10 次）。主要观察指标为 100mm 视觉模拟评分（VAS）疼痛和疾病特异性问卷；西部安大略省和麦克马斯特大学骨关节炎指数（WOMAC）。共纳入 61 例平均年龄 57.9±9.7 岁的膝骨关节炎患者。凝胶（n=30）和乳膏（n=31）声透皮治疗组的基线 VAS 和 WOMAC 评分相似（p＞0.05）。治疗后，两组 VAS 疼痛评分和 WOMAC 评分均较基线改善。在凝胶声透皮治疗组，VAS 评分的改善高于乳膏声透皮治疗组（p＜0.001）。同样，凝胶声透皮治疗组 WOMAC 总分的改善也高于乳膏声透皮治疗组（p＜0.001）。布洛芬声透皮治疗对膝骨关节炎患者有效。与使用同一种分子的乳膏型布洛芬相比，使用凝胶型布洛芬的声透皮治疗具有更高的临床疗效。
