Horová H, Soumarová R, Seneklová Z, Růzicková J
Klinika komplexní onkologické péce-oddĕlení radiacní onkologie, Masarykův onkologický ústav, Brno.
Cas Lek Cesk. 2003;142 Suppl 1:53-6.
Concomitant chemoradiotherapy plays an important role in the treatment of malignancies. Concomitant chemoradiotherapy improves the local control and overall survival compare to separate treatment modalities. Combined treatment leads to higher toxicity. Most frequent side effects during concomitant chemoradiotherapy are diarrhoea, mucositis, skin reactions and haematologic toxicity. Optimal combination of treatment modalities, fractionation and dosage of radiotherapy, modern planning techniques and use of radioprotective drugs could decrease the treatment toxicity.
同步放化疗在恶性肿瘤治疗中发挥着重要作用。与单独的治疗方式相比，同步放化疗可提高局部控制率和总生存率。联合治疗会导致更高的毒性。同步放化疗期间最常见的副作用是腹泻、黏膜炎、皮肤反应和血液学毒性。治疗方式、放疗分割和剂量的最佳组合、现代放疗计划技术以及放射防护药物的使用可降低治疗毒性。
