[Activity of cytokines in immunization with a vaccine against experimental tick-borne encephalitis].

An experimental double immunization of BALB/c mice with a vaccine against tick-borne encephalitis was accompanied by the production of IL-1b, IL-2, IL-4, IL-6, IL-10, IL-12, TNFa and gamma-IFN in the blood serum of animals. After the first immunization of animals with the vaccine against tick-borne encephalitis, the activity of cytokine was indicative of an activation of macrophages as well as of an activation and differentiation of T- and B-lymphocytes. After the second immunization and unlike the first one, there were changes in the production only of IL-10, IL-12 and gamma-IFN, which can be indicative of a regulation of balance between Th1 and Th2.