Kostin Ia V, Blinov D S, Moiseeva I Ia
Department of Pharmacology, Mordvinian State University, ul. Bol'shevistskaya 68, Saransk, Mordvinia, 430000 Russia.
Eksp Klin Farmakol. 2003 May-Jun;66(3):29-31.
The results of experiments on cats and dogs showed that quaternidine, a quaternary ammonium derivative of trimecaine, exceeds the structural precursors (trimecaine and lidocaine), as well as the reference drugs quinidine and propranolol, in intensity of the antiarrhythmic action upon single administration on the occlusive and reperfusive arrhythmia models. The therapeutic effect of quaternidine in animals with acute myocardial ischemia lasts for about 8 h, which more than 20 times longer as compared to the duration of action of both lidocaine and trimecaine.
对猫和狗的实验结果表明，三甲卡因的季铵衍生物四卡因，在对闭塞性和再灌注性心律失常模型单次给药时，其抗心律失常作用强度超过结构前体（三甲卡因和利多卡因）以及参比药物奎尼丁和普萘洛尔。四卡因对急性心肌缺血动物的治疗作用持续约8小时，这比利多卡因和三甲卡因的作用持续时间长20多倍。
