Balashov V P, Blinov D S, Kazachenko V N, Astashev M E, Agenosova O G
Department of Medical Biology, N. P. Ogarev Mordovian State University, Saransk, Russia.
Bull Exp Biol Med. 2005 Jun;139(6):688-91. doi: 10.1007/s10517-005-0379-y.
Complex electrophysiological study of the effects of quaternidine carried out on intact hearts from cats, myocardial fragments from rats, and single ionic channels of large edible snail showed that quaternidine demonstrates properties of class 1B antiarrhythmic drug according to Vaughan-Williams nomenclature. This agent did not suppress nomotopic pacemaker automaticity, did not change conduction in ventricles, atria, and atrioventricular junction in hearts with preserved sinus rhythm, did not prolong refractoriness of the atria and atrioventricular junction, but prolonged efficient refractory period of heart ventricles. Quaternidine decelerated rapid depolarization of the action potential, but had no effect on its duration. It did not affect potassium conductance.
对猫的完整心脏、大鼠的心肌片段以及大型食用蜗牛的单个离子通道进行的关于喹尼丁作用的复杂电生理研究表明，根据 Vaughan-Williams 命名法，喹尼丁具有 1B 类抗心律失常药物的特性。该药物不抑制正常节律的起搏器自律性，在窦性心律保存的心脏中不改变心室、心房和房室交界处的传导，不延长心房和房室交界处的不应期，但延长心室的有效不应期。喹尼丁减缓动作电位的快速去极化，但对其持续时间没有影响。它不影响钾电导。
