Stone Kimberly J, Viera Anthony J, Parman Christopher L
Naval Hospital Jacksonville, Florida 32214, USA.
Am Fam Physician. 2003 Aug 1;68(3):498-504.
Selective serotonin reuptake inhibitors (SSRIs) are widely used because of their safety, tolerability, and demonstrated efficacy across a broad range of clinical conditions. Medical literature supports the use of SSRIs for the treatment of many conditions outside of the indications approved by the U.S. Food and Drug Administration. SSRIs offer a reasonable alternative to traditional therapy for generalized anxiety disorder. A side effect of SSRIs coincidentally provides therapy for premature ejaculation. SSRIs may reduce the frequency and severity of migraine headaches and are possibly effective in reducing the pain of diabetic neuropathy. When taken in combination with tricyclic antidepressants, SSRis offer more potent therapy for fibromyalgia than either agent alone. SSRIs appear to be effective in some patients with neurocardiogenic syncope that is refractory to standard therapies. Clinical experience supported by ongoing research continues to expand on the broad array of therapeutic applications for this class of medication.
选择性5-羟色胺再摄取抑制剂（SSRIs）因其安全性、耐受性以及在广泛临床病症中已证实的疗效而被广泛使用。医学文献支持将SSRIs用于治疗美国食品药品监督管理局批准的适应症以外的多种病症。对于广泛性焦虑症，SSRIs为传统疗法提供了合理的替代方案。SSRIs的一个副作用恰好为早泄提供了治疗方法。SSRIs可能会降低偏头痛的发作频率和严重程度，并且在减轻糖尿病性神经病变的疼痛方面可能有效。当与三环类抗抑郁药联合使用时，SSRIs对纤维肌痛的治疗效果比单独使用任何一种药物都更强。SSRIs似乎对某些对标准疗法无效的神经心源性晕厥患者有效。正在进行的研究所支持的临床经验不断拓展这类药物的广泛治疗应用范围。
