Pintado V, Gómez-Mampaso E, Cobo J, Quereda C, Meseguer M A, Fortún J, Navas E, Moreno S
Infectious Diseases Department, Hospital Ramón y Cajal, Carretera de Colmenar km 9.1, 28034 Madrid, Spain.
Clin Microbiol Infect. 2003 Jul;9(7):716-20. doi: 10.1046/j.1469-0691.2003.00588.x.
During the period 1981-2000, we diagnosed eight cases of HIV-Nocardia co-infection (0.38% of AIDS cases). Six were males, and the mean age was 28.6 years. The most common risk factor for HIV infection was intravenous drug abuse. Most patients were severely immunodepressed at the time of diagnosis (mean CD4+ count, 35 cells/ micro L). The clinical forms of nocardiosis seen were pulmonary infection in three, skin or soft tissue infection in three, disseminated in one, and pulmonary colonization in one. Most patients were given sulfonamides, and a clinical response was observed in six of seven treated patients. However, two patients with pulmonary disease died from progressive infection. Although its incidence is very low among AIDS patients, nocardiosis is associated with high morbidity and mortality among HIV-infected individuals.
在1981年至2000年期间，我们诊断出8例HIV-诺卡菌合并感染病例（占艾滋病病例的0.38%）。其中6例为男性，平均年龄为28.6岁。感染HIV最常见的危险因素是静脉注射毒品。大多数患者在诊断时免疫严重抑制（平均CD4+细胞计数为35个/微升）。所见的诺卡菌病临床类型为肺部感染3例、皮肤或软组织感染3例、播散性感染1例、肺部定植1例。大多数患者接受了磺胺类药物治疗，7例接受治疗的患者中有6例观察到临床反应。然而，2例肺部疾病患者死于进行性感染。尽管诺卡菌病在艾滋病患者中的发病率非常低，但在HIV感染个体中与高发病率和高死亡率相关。
