Matysiak-Budnik T, Heyman M, Mégraud F
INSERM EMI-0212, Faculté de Médecine Necker-Enfants Malades, Paris, France.
Aliment Pharmacol Ther. 2003 Jul;18 Suppl 1:55-62. doi: 10.1046/j.1365-2036.18.s1.6.x.
Rebamipide exerts a positive effect on the digestive epithelial barrier by reinforcing its integrity in normal and in inflammatory conditions, and by normalizing the macromolecular transport across this barrier, increased by Helicobacter infection. Moreover, in mice, rebamipide is capable of diminishing allergic sensitization and of counteracting the inhibitory effect of Helicobacter pylori on oral tolerance to dietary antigens. These properties of rebamipide could explain its anti-inflammatory activity with respect to the digestive mucosa and could provide protection against allergic sensitization to foreign antigens in susceptible individuals.
瑞巴派特通过在正常和炎症条件下增强消化上皮屏障的完整性，以及使因幽门螺杆菌感染而增加的跨该屏障的大分子转运正常化，从而对消化上皮屏障产生积极作用。此外，在小鼠中，瑞巴派特能够减少过敏致敏，并抵消幽门螺杆菌对口服饮食抗原耐受性的抑制作用。瑞巴派特的这些特性可以解释其对消化黏膜的抗炎活性，并可为易感个体提供针对对外源抗原过敏致敏的保护作用。
