Kudur Mohan H, Hulmani Manjunath
Department of Dermatology and Venereology, Srinivas Institute of Medical Sciences and Research Centre, Mukka, Surathkal, Mangalore, Karnataka, India.
Indian J Dermatol. 2013 Sep;58(5):352-4. doi: 10.4103/0019-5154.117298.
Rebamipide is an amino acid analog of 2 (1H)-quinolinone. It is being introduced and used since 1980 for the treatment of peptic ulcer. Its therapeutic use in recurrent aphthous ulcer was not known. It acts by the decrease in oxygen radicals, increase in blood flow and production of protective prostaglandins in ulcer mucosa, which accelerates the process of healing. In this article, we focus on the pharmacodynamics, pharmacokinetics, side-effects and other therapeutic uses of Rebamipide. It will be a new and effective drug in the dermatologists' drug armamentarium for the treatment of aphthous ulcers and related diseases.
瑞巴派特是2（1H）-喹啉酮的氨基酸类似物。自1980年以来一直被引入并用于治疗消化性溃疡。其在复发性阿弗他溃疡中的治疗用途尚不为人所知。它通过减少氧自由基、增加血流量以及在溃疡黏膜中产生保护性前列腺素起作用，从而加速愈合过程。在本文中，我们重点关注瑞巴派特的药效学、药代动力学、副作用及其他治疗用途。它将成为皮肤科医生治疗阿弗他溃疡及相关疾病的药物库中的一种新型有效药物。
