Chen Honglei, Zhang Shumin M, Hernán Miguel A, Schwarzschild Michael A, Willett Walter C, Colditz Graham A, Speizer Frank E, Ascherio Alberto
Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.
Arch Neurol. 2003 Aug;60(8):1059-64. doi: 10.1001/archneur.60.8.1059.
Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce dopaminergic neuron degeneration in animal models of Parkinson disease (PD). However, no epidemiological data have been available on NSAID use and the risk of PD.
To investigate prospectively whether the use of nonaspirin NSAIDs or aspirin is associated with decreased PD risk.
DESIGN, SETTINGS, AND PARTICIPANTS: Prospective cohorts of 44 057 men and 98 845 women free of PD, stroke, or cancer (Health Professionals Follow-up Study, 1986-2000, and Nurses' Health Study, 1980-1998). Main Outcome Measure Newly diagnosed PD.
We documented 415 incident PD cases (236 men and 179 women). Participants who reported regular use of nonaspirin NSAIDs at the beginning of the study had a lower risk of PD than nonregular users during the follow-up; the pooled multivariate relative risk was 0.55 (95% confidence interval, 0.32-0.96, P =.04). Compared with nonusers, a nonsignificantly lower risk of PD was also observed among men and women who took 2 or more tablets of aspirin per day (relative risk, 0.56; 95% confidence interval, 0.26-1.21).
These findings are consistent with the hypothesis that use of NSAIDs may delay or prevent the onset of PD.
在帕金森病（PD）动物模型中，非甾体抗炎药（NSAIDs）可减少多巴胺能神经元变性。然而，尚无关于NSAIDs使用与PD风险的流行病学数据。
前瞻性调查非阿司匹林NSAIDs或阿司匹林的使用是否与PD风险降低相关。
设计、地点和参与者：44057名男性和98845名女性的前瞻性队列，这些人无PD、中风或癌症（卫生专业人员随访研究，1986 - 2000年；护士健康研究，1980 - 1998年）。主要结局指标为新诊断的PD。
我们记录了415例PD病例（236名男性和179名女性）。在研究开始时报告经常使用非阿司匹林NSAIDs的参与者在随访期间患PD的风险低于非经常使用者；汇总的多变量相对风险为0.55（95%置信区间，0.32 - 0.96，P = 0.04）。与未使用者相比，每天服用2片或更多片阿司匹林的男性和女性患PD的风险也有非显著性降低（相对风险，0.56；95%置信区间，0.26 - 1.21）。
这些发现与NSAIDs的使用可能延迟或预防PD发病的假设一致。
