甲状腺激素作用：一份约束性契约。
Thyroid hormone action: a binding contract.
作者信息
Lazar Mitchell A
机构信息
University of Pennsylvania School of Medicine, 611 Clinical Research Building, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104-6149, USA.
出版信息
J Clin Invest. 2003 Aug;112(4):497-9. doi: 10.1172/JCI19479.
Abstract
Thyroid hormones are critical for differentiation, growth, and metabolism. A new study investigating the biological role of the TH receptor TR-beta has demonstrated that DNA binding is critical for most of its functions, but also suggests that novel mechanisms independent of DNA binding may contribute to regulation of auditory function by TR-beta.
摘要
甲状腺激素对于分化、生长和新陈代谢至关重要。一项研究甲状腺激素受体TR-β生物学作用的新研究表明，DNA结合对其大多数功能至关重要，但也表明，独立于DNA结合的新机制可能有助于TR-β对听觉功能的调节。
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