Feuer Ralph, Mena Ignacio, Pagarigan Robb R, Hassett Daniel E, Whitton J Lindsay
Department of Neuropharmacology, CVN-9, The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 92037, USA.
Med Microbiol Immunol. 2004 May;193(2-3):83-90. doi: 10.1007/s00430-003-0192-z. Epub 2003 Aug 19.
Coxsackieviruses (CV) are characterized by their ability to cause cytopathic effects in tissue culture and by their capacity to initiate acute disease by inducing apoptosis within targeted organs in vivo. These viruses are considered highly cytolytic, but can establish persistence/latency in susceptible cells, indicating that a regulatory mechanism may exist to shut off viral protein synthesis and replication under certain situations. The persistence of coxsackieviral RNA is of particular medical interest due to its association with chronic human diseases such as dilated cardiomyopathy and chronic inflammatory myopathy. Here, we discuss the potential mechanisms regulating coxsackievirus replication, and the ability of viral RNA to remain in an apparent latent state within quiescent cells.
柯萨奇病毒（CV）的特点是能够在组织培养中引起细胞病变效应，以及在体内通过诱导靶器官内的细胞凋亡引发急性疾病。这些病毒被认为具有高度细胞溶解性，但可在易感细胞中建立持续性/潜伏状态，这表明在某些情况下可能存在一种调节机制来关闭病毒蛋白合成和复制。柯萨奇病毒RNA的持续性因其与扩张型心肌病和慢性炎症性肌病等慢性人类疾病的关联而具有特殊的医学意义。在此，我们讨论调节柯萨奇病毒复制的潜在机制，以及病毒RNA在静止细胞中保持明显潜伏状态的能力。
