20号染色体长臂的频繁获得和18号染色体长臂的缺失与肠型胃癌的淋巴结转移相关。
Frequent gains of 20q and losses of 18q are associated with lymph node metastasis in intestinal-type gastric cancer.
作者信息
Hidaka Shigekazu, Yasutake Toru, Kondo Masamichi, Takeshita Hiroak, Yano Hiroshi, Haseba Masatoshi, Tsuji Takashi, Sawai Terumitsu, Nakagoe Tohru, Tagawa Yutaka
机构信息
Division of Surgical Oncology, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1, Sakamoto Machi, Nagasaki City, Nagasaki 852-8501, Japan.
出版信息
Anticancer Res. 2003 Jul-Aug;23(4):3353-7.
BACKGROUND
The genetic aberrations associated with development and progression of gastric carcinomas (GCs) are poorly understood. The aim of this study was to identify chromosomal aberrations associated with the development and/or progression of intestinal-type GC.
MATERIALS AND METHODS
Comparative genomic hybridization (CGH) analysis was applied to 36 intestinal-type GCs. We compared chromosomal aberrations detected by CGH analysis with clinicopathological parameters.
RESULTS
Frequent gains of DNA copy number were found on 8q, 13q, 20q, 3q, 6q and losses were found on 17p, 18q in intestinal-type GCs. No significant differences were observed in the chromosomal aberrations between tumor stage, tumor location, peritoneal dissemination, liver metastasis or other distant metastasis. However, the frequencies of 20q12-13 gain and 18q21-22 loss were significantly higher in tumors with lymph node metastasis than in those without metastasis.
CONCLUSION
Gains of 20q and losses of 18q may contribute to lymph node metastasis and the malignant phenotype in intestinal-type GCs.
背景
与胃癌（GC）发生和进展相关的基因畸变了解甚少。本研究旨在鉴定与肠型GC发生和/或进展相关的染色体畸变。
材料与方法
对36例肠型GC进行比较基因组杂交（CGH）分析。我们将CGH分析检测到的染色体畸变与临床病理参数进行比较。
结果
在肠型GC中发现8q、13q、20q、3q的DNA拷贝数频繁增加，17p、18q的DNA拷贝数减少。在肿瘤分期、肿瘤位置、腹膜播散、肝转移或其他远处转移之间，染色体畸变未观察到显著差异。然而，有淋巴结转移的肿瘤中20q12 - 13增加和18q21 - 22缺失的频率显著高于无转移的肿瘤。
结论
20q增加和18q缺失可能促成肠型GC的淋巴结转移和恶性表型。
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