2-氨基-2-脱氧糖的立体选择性合成：N-烷基-D-阿洛糖胺

Stereoselective synthesis of 2-amino-2-deoxysugars: N-alkyl-D-allosamines.

作者信息

Liu Hong-Min, Zhang Fuyi, Wang Shaomin

机构信息

Department of Chemistry, Zhengzhou University, Zhengzhou 450052, P. R. China.

出版信息

Org Biomol Chem. 2003 May 21;1(10):1641-2. doi: 10.1039/b302587j.

DOI:10.1039/b302587j

PMID:12926348

Abstract

Stereoselective synthesis of N-alkyl-D-allosamines, designed for the preparation of N-alkyl derivatives of allosamidin (a chitinase inhibitor), is achieved by a 'carbonyl group transfer' reaction followed by stereoselective reduction and this method represents the first example of N-alkyl-D-allosamines synthesized from a 2-oxosugar.

摘要

N-烷基-D-阿洛糖胺的立体选择性合成是通过“羰基转移”反应，随后进行立体选择性还原实现的，该合成方法旨在制备别洛沙定（一种几丁质酶抑制剂）的N-烷基衍生物，此方法是由2-氧代糖合成N-烷基-D-阿洛糖胺的首个实例。